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Design and synthesis of highly selective in vitro and in vivo uterine receptor antagonists of oxytocin: comparisons with Atosiban

✍ Scribed by MANNING, M. ;MITEVA, K. ;PANCHEVA, S. ;STOEV, S. ;WO, N.C. ;CHAN, W.Y.


Book ID
115099736
Publisher
Wiley (Blackwell Publishing)
Year
2009
Tongue
English
Weight
855 KB
Volume
46
Category
Article
ISSN
0367-8377

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The peptide oxytocin (OT) antagonist atosiban, approved for tocolytic use in Europe (under the tradename Tractocile), represents an important new therapeutic advance for the treatment of premature labor. This paper presents some new peptide OT antagonists which offer promise as superior tocolytics.