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Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin

✍ Scribed by Gerald Gimpl; Rolf Postina; Falk Fahrenholz; Torsten Reinheimer

Book ID
113585263
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
341 KB
Volume
510
Category
Article
ISSN
0014-2999

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Design of peptide oxytocin antagonists w
Design of peptide oxytocin antagonists with strikingly higher affinities and selectivities for the human oxytocin receptor than atosiban
✍ Maurice Manning; Ling Ling Cheng; Stoytcho Stoev; Nga Ching Wo; W. Y Chan; Hazel πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 219 KB

The peptide oxytocin (OT) antagonist atosiban, approved for tocolytic use in Europe (under the tradename Tractocile), represents an important new therapeutic advance for the treatment of premature labor. This paper presents some new peptide OT antagonists which offer promise as superior tocolytics.