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Design of potent oxytocin antagonists featuring D-tryptophan at position 2

✍ Scribed by Flouret, George; Brieher, William; Mahan, Kevin; Wilson, Laird


Book ID
126895279
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
740 KB
Volume
34
Category
Article
ISSN
0022-2623

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Antagonists of oxytocin featuring replac
✍ Dr. George Flouret; Tadeusz Majewski; Lajos Balaspiri; William Brieher; Kevin Ma 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 155 KB

## Abstract Twenty analogues were synthesized of [Pmp^1^, D‐Trp^2^, Arg^8^]oxytocin, PA, (Pmp = β,β‐pentamethylene‐β‐mercaptopropionic acid), a potent antagonist of the uterotonic effect of oxytocin in the rat (uterotonic test __in vitro__, pA~2~ = 7.77) and in the baboon. Systematic substitution o

Analogues of a potent oxytocin antagonis
✍ Dr George Flouret; Olivier Chaloin; Jirina Slaninová 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB

## Abstract Twelve analogues were synthesized, their structure derived from modifications of [(S)Pmp^1^, D‐Trp^2^, Pen^6^, Arg^8^]oxytocin, PA, in which (S)Pmp = β,β‐(3‐thiapentamethylene‐β‐mercaptopropionic acid). PA is a potent antagonist of the uterotonic effect of oxytocin in the rat (uterotoni