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Design and synthesis of DNA intercalating crown ether molecules

✍ Scribed by A. Basak; H. Dugas

Book ID
104218038
Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
239 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

We describe the synthesis of a series of novel mono-and bis-intercalant crown ethers 1 and 2, having either a methidium or a psoralen function covalently attached to the macrocyclic ring with well-defined stereo chemistry.

Their binding efficiency to DNA duplex has been evaluated.

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