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Design, synthesis, DNA binding, and biological activity of a series of DNA minor-groove-binding intercalating drugs

✍ Scribed by Christian Bailly; Jean-Pierre Henichart; Nicole Pommery; Raymond Houssin


Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
925 KB
Volume
78
Category
Article
ISSN
0022-3549

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Viscosimetric and kinetic results allow one to characterize three modes of DNA binding in the ellipticine series: ( 1 ) Ellipticine and its 9 methoxy derivative, which present maximal DNA lengthening properties and bind DNA through a single step mechanism, can be considered as pure intercalators. (