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Design and synthesis of threading intercalators to target DNA

✍ Scribed by Lesley A. Howell; Rosul Gulam; Anja Mueller; Maria A. O’Connell; Mark Searcey

Book ID
104004960
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
452 KB
Volume
20
Category
Article
ISSN
0960-894X

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Design and synthesis of DNA intercalatin
Design and synthesis of DNA intercalating crown ether molecules
✍ A. Basak; H. Dugas 📂 Article 📅 1986 🏛 Elsevier Science 🌐 French ⚖ 239 KB

We describe the synthesis of a series of novel mono-and bis-intercalant crown ethers 1 and 2, having either a methidium or a psoralen function covalently attached to the macrocyclic ring with well-defined stereo chemistry. Their binding efficiency to DNA duplex has been evaluated.