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Design and synthesis of a novel bis-crown ether carrier molecule mimic of (Na+,K+)-ATPase

✍ Scribed by H. Dugas; P. Brunet; J. Desroches

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
209 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

A new bis-crown ether carrier molecule 3b with an ammonium tail was synthesized to mimic some of the properties of (Na+,K+)-ATPase activity. At low pH, the ammonium salt shows stabilization by intramolecular hydrogen bonding with the 18-crown-6 portion of the molecule and the compound has some selectivity for the transport of Na+ over K+ ions. As the pH is increased, the Na+ and P? ion-binding ability changes and in the free amino form, the host molecule carries both Na+ and ti ions at comparable rates.

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