Design and synthesis of all diastereomers of cyclic pseudo-dipeptides as mimics of cyclic CXCR4 pentapeptide antagonists
β Scribed by Cluzeau, J?r?me; Oishi, Shinya; Ohno, Hiroaki; Wang, Zixuan; Evans, Barry; Peiper, Stephen C.; Fujii, Nobutaka
- Book ID
- 118744414
- Publisher
- Royal Society of Chemistry
- Year
- 2007
- Tongue
- English
- Weight
- 250 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1477-0520
- DOI
- 10.1039/B702649H
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Six cyclic pentapeptides containing two or three non-protein amino acids have been synthesized by cyclization of linear precursors in dilute solution and characterized by TLC. HPLC, NMR, melting point. specific rotation etc. A total of 72 cyclization reactions were carried out to study the factors t
4 00 ,6 00 -Didehydro-cADPcR (3), an unsaturated carbocyclic ribose analog of a Ca 2+ -mobilizing second messenger cyclic ADP-ribose (cADPR), was designed and successfully synthesized using a key intramolecular condensation reaction forming the 18-membered pyrophosphate ring structure with a S-pheny