Design and synthesis of nonpeptidal endothelin receptor antagonists based on the structure of a cyclic pentapeptide
β Scribed by Natesan Murugesan; Zhengxiang Gu; Ving Lee; Maria L. Webb; Eddie C.-K. Liu; Mark Hermsmeier; John T. Hunt
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 288 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0960-894X
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The search for heterocyclic scaffolds for the design of non-peptidic and highly selective agonists or antagonists of peptide hormone receptors led to 4-N-benzyl-2,3,4,5,6,7-hexahydro-1H-1,4,7-benzotriazonin-2,6-dione with a 9-membered core structure as a new low mass lead compound that exhibits subm