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Design and Synthesis of 3‘- and 5‘- O -(3-Benzenesulfonylfuroxan-4-yl)-2‘-deoxyuridines: Biological Evaluation as Hybrid Nitric Oxide Donor−Nucleoside Anticancer Agents

✍ Scribed by Moharram, Sameh; Zhou, Aihua; Wiebe, Leonard I.; Knaus, Edward E.

Book ID: 120651192
Publisher: American Chemical Society
Year: 2004
Tongue: English
Weight: 104 KB
Volume: 47
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm030544m

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## Abstract A series of novel 4__β__‐[(4‐substituted)‐1,2,3‐triazol‐1‐yl]podophyllotoxin derivatives were synthesized by employing Cu^I^‐catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT‐29, HCT‐15, 502713, HOP‐62, A‐549, MCF‐