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Synthesis of 3‘- and 5‘-Nitrooxy Pyrimidine Nucleoside Nitrate Esters: “Nitric Oxide Donor” Agents for Evaluation as Anticancer and Antiviral Agents

✍ Scribed by Naimi, Ebrahim; Zhou, Aihua; Khalili, Panteha; Wiebe, Leonard I.; Balzarini, Jan; De Clercq, Erik; Knaus, Edward E.


Book ID
127396165
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
142 KB
Volume
46
Category
Article
ISSN
0022-2623

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a b s t r a c t Pyrroles and pyrrolo [2,3-d]pyrimidines were reported to act as potent anticancer agents, in this work, a series of novel 2-substituted-3-cyano-4-phenyl-pyrrole 5, 6, 11-18, and 5-phenyl-pyrrolo[2,3-d]pyrimidine derivatives 7-10, 19-24 bearing either sulfathiazole or sulfapyridine we