𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Design and efficient synthesis of A-278637 derivatives as potential potassium channel opener

✍ Scribed by Tuanjie Li; Xiaodong Feng; Changsheng Yao; Chenxia Yu; Bei Jiang; Shujiang Tu


Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
342 KB
Volume
21
Category
Article
ISSN
0960-894X

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


ChemInform Abstract: Design and Efficien
✍ Tuanjie Li; Xiaodong Feng; Changsheng Yao; Chenxia Yu; Bei Jiang; Shujiang Tu 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 25 KB 👁 1 views

## Abstract Following a promising scaffold, a series of novel thieno[3,2‐b]quinoline derivatives (IV) are synthesized by one‐pot three‐component reaction under solvent‐ and catalyst‐free conditions.

Synthesis of 2-aminoquinazolinc-4(3H)-on
✍ BÉNÉDicte Erb; Rufine Akue; Benoît Rigo; Bernard Pirotte; Daniel Couturier 📂 Article 📅 2000 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 486 KB

## Abstract Starting from 2‐thioxoquinazolin‐4‐one, the synthesis of 2‐amino‐4(3__H__)‐one derivatives, structurally related to potassium channels openers pinacidil and diazoxide, is described.

ChemInform Abstract: Synthesis of 2-Amin
✍ Benedicte Erb; Rufine Akue; Benoit Rigo; Bernard Pirotte; Daniel Couturier 📂 Article 📅 2000 🏛 John Wiley and Sons ⚖ 30 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

ChemInform Abstract: Synthesis and Struc
✍ K. YOSHIIZUMI; S. IKEDA; N. NISHIMURA; K. YOSHINO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 1 views

Synthesis and Structure-Activity Relationships of Thienylcyanoguanidine Derivatives as Potassium Channel Openers. -A series of thienylcyanoguanidine derivatives [cf. (V), (X), (XIII)] is synthesized and evaluated for their smooth muscle relaxation activity in vitro. Among the newly synthesized comp

Synthesis of 2-amino-1,4-dihydro-4-quino
✍ Béanéadicte Erb; Benoît Rigo; Bernard Pirotte; Daniel Couturier 📂 Article 📅 2002 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 158 KB

## Abstract Starting from 5‐bismethylthiomethylene Meldrum's acid, the synthesis of 5‐diaminomethylene Meldrum's acids and 2‐aminoquinolone derivatives, structurally related to potassium channels openers pinacidil and diazoxide, is described.

Synthesis of carbon-14 and stable isotop
✍ Steen K. Johansen; Jesper B. Kristensen; Lars K. Müller; Claus U. Jessen; Christ 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 133 KB

## Abstract Currently, NN414, a potent __β__‐cell selective potassium channel opener, is undergoing clinical trials for the treatment of type 2 diabetes. Here, we report the synthesis of carbon‐14 and stable isotope labelled NN414 for use in metabolic studies and as an internal standard in pharmaco