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Synthesis of 2-aminoquinazolinc-4(3H)-one derivatives as potential potassium channel openers
✍ Scribed by BÉNÉDicte Erb; Rufine Akue; Benoît Rigo; Bernard Pirotte; Daniel Couturier
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2000
- Tongue
- English
- Weight
- 486 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
Abstract
Starting from 2‐thioxoquinazolin‐4‐one, the synthesis of 2‐amino‐4(3__H__)‐one derivatives, structurally related to potassium channels openers pinacidil and diazoxide, is described.
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## Abstract Starting from 5‐bismethylthiomethylene Meldrum's acid, the synthesis of 5‐diaminomethylene Meldrum's acids and 2‐aminoquinolone derivatives, structurally related to potassium channels openers pinacidil and diazoxide, is described.
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## Abstract Following a promising scaffold, a series of novel thieno[3,2‐b]quinoline derivatives (IV) are synthesized by one‐pot three‐component reaction under solvent‐ and catalyst‐free conditions.