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ChemInform Abstract: Synthesis and Structure—Activity Relationships of Thienylcyanoguanidine Derivatives as Potassium Channel Openers.

✍ Scribed by K. YOSHIIZUMI; S. IKEDA; N. NISHIMURA; K. YOSHINO

Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
29
Category
Article
ISSN
0931-7597

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✦ Synopsis

Synthesis and Structure-Activity Relationships of Thienylcyanoguanidine Derivatives as Potassium Channel Openers.

-A series of thienylcyanoguanidine derivatives [cf. (V), (X), (XIII)] is synthesized and evaluated for their smooth muscle relaxation activity in vitro. Among the newly synthesized compounds, (Va) and (Xc) exhibit excellent activity which is proven to be based on potassium channel-opening action. -(YOSHIIZUMI,

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