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Dementia in people with Down's syndrome

✍ Scribed by Janette Tyrrell; Mary Cosgrave; Mary McCarron; Janet McPherson; Johnston Calvert; Alan Kelly; Martin McLaughlin; Michael Gill; Brian. A. Lawlor

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
74 KB
Volume
16
Category
Article
ISSN
0885-6230

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✦ Synopsis

Abstract

Objectives

To determine the prevalence of dementia in an Irish sample of people with Down's syndrome (DS) and to examine associated clinical characteristics of dementia in this group.

Method

285 people with DS (Age 35–74 years, mean age ± SD 46.5 ± 8.2 years) were included in this cross‐sectional study. The diagnosis of dementia was made using modified DSMIV criteria. Cognitive tests used were the Down's syndrome Mental Status Examination (DSMSE), Test for Severe Impairment (TSI) and adaptive function was measured by the Daily Living Skills Questionnaire (DLSQ).

Results

The overall prevalence of dementia was 13.3%. The presence of dementia was associated with epilepsy, myoclonus, and head injury. The demented DS group were significantly older (n = 38, mean age 54.7 years SD ± 7.5) than the non‐demented (n = 246, mean age 45.6, SD ± 7.3). The TSI and DLSQ had a satisfactory spread of scores without β€˜floor’ or β€˜ceiling’ effects in people with moderate and severe learning disability. Median scores in demented versus the non‐demented groups were significantly different for each measure of function.

Conclusions

Dementia had a prevalence of 13.3% and occurred at a mean age of 54.7 years. The combination of DLSQ score, age and presence of epilepsy were found to predict presence of dementia. Copyright Β© 2001 John Wiley & Sons, Ltd.

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