Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome
β Scribed by Yaoita, Yoshio; Honjo, Tasuku
- Book ID
- 109719497
- Publisher
- Nature Publishing Group
- Year
- 1980
- Tongue
- English
- Weight
- 751 KB
- Volume
- 286
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/286850a0
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π SIMILAR VOLUMES
The constant region of the human immunoglobulin heavy chain (IGHC) is encoded by a cluster of genes near the telomere of chromosome 14q. Deletions and duplications of single or multiple genes in the cluster have been identified, but little information about the breakpoint junctions has been availabl
The hybridoma PTF-02 secretes an antibody against pig transferrin. Rearranged genes for heavy and light immunoglobulin chains have been studied in the genomes of this hybridoma and in the parent myeloma P3-X63.Ag8.653. The hybridoma was shown to contain three rearranged allelic variants of the heavy