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Transcription of immunoglobulin heavy-chain sequences from the excluded allele

✍ Scribed by Ponte, Phyllis A.; Siekevitz, Miriam; Schwartz, Richard C.; Gefter, Malcolm L.; Sonenshein, Gail E.


Book ID
109723237
Publisher
Nature Publishing Group
Year
1981
Tongue
English
Weight
407 KB
Volume
291
Category
Article
ISSN
0028-0836

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During the initial stages of B lymphocyte differentiation heavy chain variable (VH), diversity (DH) and joining (JH) gene segments recombine to form a functional heavy chain variable region (VDJ) gene. Evidence for genetic polymorphism of the human JH gene segments has been obtained from mature rear