Deletion mapping of H-Y antigen to the long arm of the human Y chromosome
β Scribed by Cantrell, Michael A.; Bogan, Jonathan S.; Simpson, Elizabeth; Bicknell, James N.; Goulmy, Els; Chandler, Phillip; Pagon, Roberta A.; Walker, David C.; Thuline, Horace C.; Graham, John M.
- Book ID
- 122758259
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 907 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0888-7543
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DNAs of four individuals demonstrating abnormalities in sexual development and mosaic 45,XO/ 46,XY karyotypes with terminal deletions of Yq were studied using a number of Y-specific probes. The results of these analyses allowed us to map several known DNA fragments within deletion interval 6 in the
Cytogenetic and molecular genetic analyses have shown that a tumor-suppressor gene for human meningioma is located on the long arm of chromosome 22. Recently, somatic mutations of the NF2 gene have been identified in sporadic meningiomas. However, tumorigenesis of certain cases of meningioma cannot
H-Y antigen expression was detected on cells from an individual having a presumptive 45,X/46,X,i(Yp) karyotype, but was absent on cells from another person having a 46,X,i(Yq) karyotype. This suggests that the short arm of the human Y chromosome is essential for H-Y antigen expression, at least in t