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Defective DNA double-strand break repair in pediatric systemic lupus erythematosus

✍ Scribed by Robert C. Davies; Kelly Pettijohn; Francesca Fike; Jiexi Wang; Shareef A. Nahas; Rashmi Tunuguntla; Hailiang Hu; Richard A. Gatti; Deborah McCurdy


Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
783 KB
Volume
64
Category
Article
ISSN
0004-3591

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Nijmegen breakage syndrome: consequences
✍ Martin Digweed; AndrΓ© Reis; Karl Sperling πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 85 KB

The autosomal recessive genetic disorder, Nijmegen Breakage Syndrome, is characterised by an excessively high risk for the development of lymphatic tumours and an extreme sensitivity towards ionising radiation. The most likely explanation for these characteristics, a deficiency in the repair of DNA