Decreased production of interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus
β Scribed by David A. Horwitz; J. Dixon Gray; Steven C. Behrendsen; Marek Kubin; Manthrasalam Rengaraju; Kazuo Ohtsuka; Giorgio Trinchieri
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 628 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0004-3591
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Using radiolabeled interleukin-2 (IL-2), affinity cross-linking and binding assays revealed that the expression of intermediate-affinity IL-2 binding molecules (p70/75) on freshly prepared T cells from patients with systemic lupus erythematosus (SLE) was significantly decreased in comparison with th
Decreased interleukin-2 (IL-2) production by lymphocytes in vitro has previously been demonstrated in patients with systemic lupus erythematosus (SLE). In the present study, we examined whether inhibitory factors in SLE patient sera are involved in defective IL-2 production. Our results indicate tha