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Reconstitution of deficient T cell receptor ζ chain restores T cell signaling and augments T cell receptor/CD3–induced interleukin-2 production in patients with systemic lupus erythematosus

✍ Scribed by Madhusoodana P. Nambiar; Carolyn U. Fisher; Vishal G. Warke; Sandeep Krishnan; Jeanne P. Mitchell; Nancy Delaney; George C. Tsokos


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
296 KB
Volume
48
Category
Article
ISSN
0004-3591

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T cell signaling abnormalities in system
✍ Madhusoodana P. Nambiar; Edith J. Enyedy; Vishal G. Warke; Sandeep Krishnan; Gre 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 193 KB 👁 2 views

## Objective. T cells from patients with systemic lupus erythematosus (SLE ) display antigen receptormediated signaling aberrations associated with defective T cell receptor (TCR) chain protein and messenger RNA (mRNA) expression. This study was undertaken to explore the possibility that coding-re