Single-nucleotide polymorphisms of T cell receptor ζ chain in patients with systemic lupus erythematosus
✍ Scribed by Jianming Wu; Jeffrey C. Edberg; Andrew W. Gibson; Betty Tsao; Robert P. Kimberly
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 118 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
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## Objective. T cells from patients with systemic lupus erythematosus (SLE ) display antigen receptormediated signaling aberrations associated with defective T cell receptor (TCR) chain protein and messenger RNA (mRNA) expression. This study was undertaken to explore the possibility that coding-re
## Abstract ## Objective Genome‐wide association (GWA) studies in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in Caucasian populations have independently identified risk variants in and near the tumor necrosis factor α (TNFα)–induced protein 3 gene (__TNFAIP3__), which is cruc