Decreased expression of interleukin-2 binding molecules (p70/75) in T cells from patients with systemic lupus erythematosus

✍ Scribed by Toshio Tanaka; Osamu Saiki; Shigeru Negoro; Tsuyoshi Igarashi; Taro Kuritani; Hideki Hara; Masaki Suemura; Susumu Kishimoto

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 689 KB
• Volume: 32
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/anr.1780320507

✦ Synopsis

Using radiolabeled interleukin-2 (IL-2), affinity cross-linking and binding assays revealed that the expression of intermediate-affinity IL-2 binding molecules (p70/75) on freshly prepared T cells from patients with systemic lupus erythematosus (SLE) was significantly decreased in comparison with that in normal subjects. The proliferative response of T cells to high doses of IL-2 was also reduced in patients with SLE. The decreased expression of ~70175 reflects the hyporesponsiveness to IL-2 of T cells in patients with SLE.

Systemic lupus erythematosus (SLE) is a disorder representative of autoimmune diseases, and is characterized by polyclonal B cell activation. Hyperactive B cells are known to produce excessive amounts of autoantibodies and immunoglobulins ( 14). Also, dysfunctions of T cells or abnormalities of macrophages, independently or related to polyclonal B cell activation, have been reported (5-10).