Dysregulation of interleukin-10 production in relatives of patients with systemic lupus erythematosus
โ Scribed by Luis Llorente; Yvonne Richaud-Patin; Jacques Couderc; Donato Alarcon-Segovia; Rodrigo Ruiz-Soto; Natasha Alcocer-Castillejos; Jorge Alcocer-Varela; Julio Granados; Susana Bahena; Pierre Galanaud; Dominique Emilie
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 710 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
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Objective. To study the genetic association of interleukin-10 (IL-10) promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus (SLE), and to investigate possible associations with clinical manifestations of the disease. Methods. DNA was extracted from 88 Chinese patient
Decreased interleukin-2 (IL-2) production by lymphocytes in vitro has previously been demonstrated in patients with systemic lupus erythematosus (SLE). In the present study, we examined whether inhibitory factors in SLE patient sera are involved in defective IL-2 production. Our results indicate tha