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Decreased expression and frequent allelic inactivation of the RUNX3 gene at 1p36 in human hepatocellular carcinoma

✍ Scribed by Toshiaki Mori; Shuji Nomoto; Katsumi Koshikawa; Tsutomu Fujii; Mitsuru Sakai; Yoko Nishikawa; Soichiro Inoue; Shin Takeda; Tetsuya Kaneko; Akimasa Nakao

Book ID: 111237478
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 376 KB
Volume: 25
Category: Article
ISSN: 0106-9543
DOI: 10.1111/j.1478-3231.2005.1059.x

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The short arm of chromosome 1 is among the most frequently affected regions in various types of common adult cancers as well as in neuroblastoma. In a previous study of ours, frequent allelic imbalance at the TP73 locus at 1p36 was noted in lung cancer despite the absence of TP73 mutations. This sug