Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma
β Scribed by Park, S-W; Ludes-Meyers, J; Zimonjic, D B; Durkin, M E; Popescu, N C; Aldaz, C M
- Book ID
- 109998190
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 314 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0007-0920
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Chromosomal rearrangements unraveled by spectral karyotyping (SKY) indicated frequent chromosome 19 translocations in hepatocellular carcinoma (HCC). In an effort to characterize the aberrant 19 rearrangements in HCC, we performed positional mapping by fluorescence inβsitu hybridization
We investigated 24 hepatocellular carcinomas in Japan to find loss of heterozygosity with 15 polymorphic DNA markers that detect allelic losses at specific chromosome loci. Loss of heterozygosity on chromosomes lOq, 17p and 22q was detected in 3 of 12 (26%), 9 of 21 (43%) and 5 of 15 (33%) informati
## BACKGROUND. The 12 members of the MAGE gene family encode tumor specific antigens that are recognized by autologous cytotoxic T lymphocytes (CTL). The MAGE genes are expressed not only in melanoma but in the other malignant tumors as well. There is, however, little information on their expressi