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Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 σ gene in human hepatocellular carcinoma

✍ Scribed by Iwata, Norikazu; Yamamoto, Hiroyuki; Sasaki, Shigeru; Itoh, Fumio; Suzuki, Hiromu; Kikuchi, Takefumi; Kaneto, Hiroyuki; Iku, Shouhei; Ozeki, Itaru; Karino, Yoshiyasu


Book ID
110064210
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
327 KB
Volume
19
Category
Article
ISSN
0950-9232

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✍ Shufang Liang; Yuhuan Xu; Guobo Shen; Xinyu Zhao; Jin Zhou; Xingbin Li; Fengming 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 284 KB

## Abstract Loss of 14‐3‐3σ expression mainly by methylation‐mediated silencing has been reported in several human cancers, but the methylation status of 14‐3‐3σ in human renal carcinoma is rarely studied so far. In this report, 14‐3‐3σ expression was first examined by RT‐PCR and immunohistochemist