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Absence of mutation of the p73 gene localized at chromosome 1p36.3 in hepatocellular carcinoma

โœ Scribed by Mihara, M; Nimura, Y; Ichimiya, S; Sakiyama, S; Kajikawa, S; Adachi, W; Amano, J; Nakagawara, A

Book ID
110000896
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
68 KB
Volume
79
Category
Article
ISSN
0007-0920

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Genetic analysis ofp73 localized at chro
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โœ Ichimiya, Shingo ;Nimura, Yoshinori ;Kageyama, Hajime ;Takada, Naoyuki ;Sunahara ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 176 KB ๐Ÿ‘ 1 views

Background. Human p73, a novel homolog of p53, has recently been cloned and mapped at chromosome 1p36.3, the locus for putative tumor suppressor gene(s) of neuroblastoma (NBL) and other cancers. p73, like p53, inhibits growth and induces apoptosis in neuroblastoma and osteosarcoma cell lines. Proced

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The clinical significance of p53 gene mutation in hepatocellular carcinomas from japan
โœ Hiroshi Hayashi; Kenji Sugio; Takashi Matsumata; Eisuke Adachi; Kenji Takenaka; ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 639 KB

To clarify the clinical significance of the mutation of p53 gene in hepatocellular carcinoma (HCC), 90 resected specimens from Japanese patients were assayed using a polymerase chain reaction-single strand conformation polymorphism (PCRSSCP) analysis. p53 mutations were detected in 25 cases (27.8%)