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Cytotoxicity, Accumulation, and Efflux of Cisplatin and Its Metabolites in Human Ovarian Carcinoma Cells

โœ Scribed by Farshad H. Shirazi; J.Matshela Molepo; David J. Stewart; Cheng E. Ng; G.Peter Raaphorst; Rakesh Goel

Book ID
112266193
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
129 KB
Volume
140
Category
Article
ISSN
0041-008X

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## Abstract The clinical efficacy of cisplatinโ€based chemotherapy for ovarian cancer is frequently compromised by drug resistance or doseโ€limiting renal and neurologic toxicities. CIโ€973 (NKโ€121), a 2โ€methylโ€1, 4โ€butanediamine analogue of carboplatin, has shown little nephroโ€and neuroโ€toxicity in p