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Synergistic cytotoxic actions of cisplatin and liposomal valinomycin on human ovarian carcinoma cells

✍ Scribed by Sayed S. Daoud; Nicholas H. Forde

Publisher
Springer
Year
1991
Tongue
English
Weight
786 KB
Volume
28
Category
Article
ISSN
0344-5704

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✍ R. P. Perez; P. J. O'Dwyer; L. M. Handel; R. F. Ozols; T. C. Hamilton 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 528 KB

## Abstract The clinical efficacy of cisplatin‐based chemotherapy for ovarian cancer is frequently compromised by drug resistance or dose‐limiting renal and neurologic toxicities. CI‐973 (NK‐121), a 2‐methyl‐1, 4‐butanediamine analogue of carboplatin, has shown little nephro‐and neuro‐toxicity in p