## Abstract The clinical efficacy of cisplatin‐based chemotherapy for ovarian cancer is frequently compromised by drug resistance or dose‐limiting renal and neurologic toxicities. CI‐973 (NK‐121), a 2‐methyl‐1, 4‐butanediamine analogue of carboplatin, has shown little nephro‐and neuro‐toxicity in p
Analysis of the cytotoxic interaction between cisplatin and hyperthermia in a human ovarian carcinoma cell line
✍ Scribed by Eizo Kimura; Stephen B. Howell
- Publisher
- Springer
- Year
- 1993
- Tongue
- English
- Weight
- 627 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Human ovarian carcinoma cells (2008 and its cisplatin‐resistant sub‐line 2008/C13\*) were sensitized to cisplatin by treatment with human recombinant gamma interferon (IFNγ). IFNγ produced no significant change in the uptake of CDDP. Exposure of 2008 and 2008/C13\* cells to IFNγ resulte
## Abstract In order to elucidate the mechanisms underlying the development of chemoresistance in ovarian cancer, we have previously established the IGROV1‐R10 cisplatin‐resistant cell line by mimicking a clinical protocol of drug administration on IGROV1 human ovarian carcinoma cells. Both IGROV1
## Abstract Studies were performed to determine whether novobiocin can be used to enhance cisplatin (CDDP) cytotoxicity in a human small‐cell lung carcinoma cell line, GLC~4~/CDDP, resistant to CDDP. Continuous incubation with novobiocin enhanced the cytotoxicity of CDDP treatment 1.9‐fold in the p