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Inhibition of the UCI-107 human ovarian carcinoma cell line by a targeted cytotoxic analog of somatostatin, AN-238

โœ Scribed by Artur Plonowski; Andrew V. Schally; Miklos Koppan; Attila Nagy; Jose M. Arencibia; Balazs Csernus; Gabor Halmos

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
150 KB
Volume
92
Category
Article
ISSN
0008-543X

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Since somatostatin (sst) receptors are expressed in a high percentage of human breast cancers, we studied the effects of a targeted cytotoxic somatostatin analog (AN-238) formed by linking the highly active doxorubicin (DOX) derivative 2-pyrrolino-DOX (AN-201) to octapeptide RC-121 (D-Phe-Cys-Tyr-D-