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Potentiation of cisplatin and carboplatin cytotoxicity by amphotericin B in different human ovarian carcinoma and malignant peritoneal mesothelioma cells

✍ Scribed by Laurent Poulain; François Sichel; Hubert Crouet; François Bureau; Pascal Gauduchon; Marc Gignoux; Jean-Yves Le Talaër

Publisher
Springer
Year
1997
Tongue
English
Weight
176 KB
Volume
40
Category
Article
ISSN
0344-5704

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✍ R. P. Perez; P. J. O'Dwyer; L. M. Handel; R. F. Ozols; T. C. Hamilton 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 528 KB

## Abstract The clinical efficacy of cisplatin‐based chemotherapy for ovarian cancer is frequently compromised by drug resistance or dose‐limiting renal and neurologic toxicities. CI‐973 (NK‐121), a 2‐methyl‐1, 4‐butanediamine analogue of carboplatin, has shown little nephro‐and neuro‐toxicity in p