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Enhanced potentiation of cisplatin cytotoxicity in human ovarian carcinoma cells by prolonged glutathione depletion

✍ Scribed by Paul A. Andrews; Mark A. Schiefer; Michael P. Murphy; Stephen B. Howell


Book ID
113137093
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
443 KB
Volume
65
Category
Article
ISSN
0009-2797

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The effect of glutathione depletion on cellular toxicity of cadmium was investigated in a subpopulation (T27) of human lung carcinoma A549 cells with coordinately high glutathione levels and Cd++-resistance. Cellular glutathione levels were depleted by exposing the cells to diethyl maleate or buthio