𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Augmentation of adriamycin, melphalan, and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian carcinoma cell lines by buthionine sulfoximine mediated glutathione depletion

✍ Scribed by Thomas C. Hamilton; Margaret A. Winker; Karen G. Louie; Gerald Batist; Brent C. Behrens; Takashi Tsuruo; Karen R. Grotzinger; Wilma M. McKoy; Robert C. Young; Robert F. Ozols


Book ID
115778440
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
268 KB
Volume
34
Category
Article
ISSN
0006-2952

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Effect of buthionine sulfoximine on PtII
✍ Prakash Mistry; Swee Y. Loh; Lloyd R. Kelland; Ken R. Harrap πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 French βš– 752 KB

## Abstract Glutathione (GSH) has often been implicated in the mechanism of resistance to platinum anti‐cancer drugs. It has been suggested that GSH may reduce the cytotoxicity of these drugs by forming inactive conjugates and by enhancing the repair of DNA‐platinum crosslinks. In the present study