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Cytogenetic findings in 33 osteosarcomas

✍ Scribed by F. Mertens; N. Mandahl; C. Örndal; B. Baldetorp; H. C. F. Bauer; A. Rydholm; T. Wiebe; H. Willén; M. Åkerman; S. Heim; F. Mitelman

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
694 KB
Volume
55
Category
Article
ISSN
0020-7136

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✦ Synopsis

Thirty-three osteosarcomas ( 0 s ) were analyzed cytogenetically. Clonal chromosome changes were detected in 17 cases. Six tumors had chromosome numbers in the diploid range, 6 in the triploid range, I in the tetraploid range and I in the pentaploid range, while 3 tumors had multiple clones with different ploidy levels. Including the present 17 tumors, a total of 27 0 s with clonal aberrations have been reported. The recognizable structural rearrangements in these 27 tumors clustered to chromosome arms I p, I q, 3p. 3q, 7q, I I p, I7p and 22q. Chromosome bands I q I I, I q2 I, I q42 and 7q I I were the most frequently rearranged, and the most common numerical rearrangements were -3, -10, -13 and -15. Supernumerary ring chromosomes, in 2 tumors as the sole change, were found in all 3 parosteal OS, which is in agreement with the findings in I previously reported parosteal 0s. The association between ring formation and parosteal morphology represents the first cytogenetic-mo hologic entity among 0s.

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