Cytogenetic findings in metastases from colorectal cancer

✍ Scribed by Georgia Bardi; Luis Antonio Parada; Lilian Bomme; Nikos Pandis; Bertil Johansson; Roger Willén; Claus Fenger; Ole Kronborg; Felix Mitelman; Sverre Heim

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: French
• Weight: 87 KB
• Volume: 72
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/(sici)1097-0215(19970807)72:4<604::aid-ijc9>3.0.co;2-u

✦ Synopsis

Eighteen tumor samples from 11 patients with metastatic colorectal cancer were cytogenetically analyzed after shortterm culturing. Of the 13 metastases examined, 11 were from lymph nodes, 1 from the peritoneum and 1 from the lung. In 5 of the 11 patients, matched samples from the primary tumor and lymph node metastases were analyzed. Cytogenetic similarities between the primary and secondary lesions were found in all 5 cases, indicating that many of the chromosomal aberrations presumably occurred before disease spreading took place. Compared with the primaries, the metastases appeared to exhibit decreased clonal heterogeneity but, concurrently, an increase in the karyotypic complexity of individual clones. Among the aberrations recurrently found in metastatic lesions were del(1)(p34), i(17)(q10), 218, 2Y, 221, 17 and 120, all of which have been seen repeatedly in previous series of primary colorectal carcinomas, and del(10)(q22) and add(16)(p13), which so far have not been associated with primary tumors and which may play a particular pathogenetic role in the metastatic process.