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Different cytogenetic patterns in skeletal breast cancer metastases

✍ Scribed by Adewale Adeyinka; Nikos Pandis; Johan Nilsson; Ingrid Idvall; Fredrik Mertens; Catarina Petersson; Sverre Heim; Felix Mitelman

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
240 KB
Volume
16
Category
Article
ISSN
1045-2257

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✦ Synopsis

Short

-term cultures of breast cancer metastases to bone from two patients were analyzed cytogenetically. One metastasis had a complex hypotriploid karyotype with numerous marker chromosomes, whereas the other had simple karyotypic changes in three unrelated clones, 46,XX,t(4; I I )(p I4;p I 3)/45,XX.-I9/46,XX,del(3)(p I 3p23), suggesting that the metastasis had originated from a simultaneous invasion of multiple cells from the primary tumor. The metatasis with complex chromosomal aberrations developed quickly as part of a clinically aggressive disease, whereas that with simple changes developed more than 20 years after the initial breast cancer diagnosis. Our findings therefore indicate that the tumor karyotype may play a role in determining the clinical course in patients with breast cancer.

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