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Cytogenetic comparison of primary tumors and lymph node metastases in breast cancer patients

โœ Scribed by Nikos Pandis; Manuel R. Teixeira; Adewale Adeyinka; Helen Rizou; Georgia Bardi; Fredrik Mertens; Johan A. Andersen; Lennart Bondeson; Kostas Sfikas; Hanne Qvist; Nikiforos Apostolikas; Felix Mitelman; Sverre Heim

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
162 KB
Volume
22
Category
Article
ISSN
1045-2257

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โœฆ Synopsis

Chromosome banding analysis of primary tumors and axillary lymph node metastases from 10 breast cancer patients revealed abnormal karyotypes in all samples with cytogenetic similarities between the primary tumor and the metastasis in all informative pairs. Although karyotypically unrelated clones were also found in the lymph node samples, they were less numerous than in the primary tumors, indicating that there was more genetic heterogeneity among the neoplastic cells in the primary than in the secondary tumors. On the other hand, some of the clones had become more complex in the metastases as a result of clonal evolution, and by and large these metastatic breast cancer cases had more karyotypic anomalies than do unselected primary breast carcinomas. Among the aberrations occurring more frequently, and that consequently may predispose to disease spread, were losses of chromosomes 17 and 22 and homogeneously staining regions, a cytogenetic sign of gene amplification.

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