𝔖 Bobbio Scriptorium
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Cytogenetic findings in 31 papillary thyroid carcinomas

✍ Scribed by Lúcia Roque; Ana L. Clode; Paula Gomes; Jorge Rosa-Santos; Jorge Soares; Prof. Sérgio Castedo

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
428 KB
Volume
13
Category
Article
ISSN
1045-2257

No coin nor oath required. For personal study only.

✦ Synopsis

Chromosome studies performed on 3 I papillary thyroid carcinomas (PTCs) revealed clonal numerical and structural abnormalities in I2 tumors. The numerical clonal aberrations found were trisomy 2, trisomy 7, and loss of the Y chromosome. A nonrandom telomeric association, tas( I 5; I6)(p I );p I 3), was observed in one carcinoma. Structural alterations with a breakpoint at I Oq I I .2 were detected in two tumors. Other chromosomes involved in rearrangements were chromosomes I, 2, 3, 5,7, 9. I I, 12, and 14. The observation of clonal changes of chromosome 2 [i(2)(qIO) and trisomy 21 in two tumors, which were both histologically classified as tall-cell PTC variants, suggests that gain of 2q may be important in the development of this morphological variant.

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