Cytochrome P450 3A and their regulation
β Scribed by Oliver Burk; Leszek Wojnowski
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 295 KB
- Volume
- 369
- Category
- Article
- ISSN
- 0028-1298
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The cytochrome P450 enzyme cytochrome P450 3A4 (CYP3A4) controls the metabolism of about 60% of all drugs, and its inhibition may dramatically affect drug safety. Modulation of cytochrome P450 activity has been observed by constituents of fruit extracts including several flavonoids. The
A method for selective and reversible inhibition of the alkane hydroxylating cytochrome P-450 in growing yeast cells was developed. Using low concentrations of carbon monoxide in a specially adapted small-scale fermentor system a complete inhibition of the first step of alkane degradation was obtain