Eight compounds of plant origin with potential chemopreventive properties were studied for their effects on hamster liver microsome-mediated alkoxyresorufin O-dealkylase activity. The phytochemicals investigated were ()-catechin, chlorophyllin, crocetin, curcumin, diallyl sulphide, (-)-epigallocatec
Effect of intestinal cytochrome P450 3A on phytochemical presystemic metabolism
โ Scribed by Xia Fang; Chen Xiao-yin
- Publisher
- Chinese Association of Traditional and Western Medicine
- Year
- 2005
- Tongue
- English
- Weight
- 505 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1672-0415
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Induction of cytochrome P450 3A (CYP3A) has been suggested as a mechanism of action of ursodeoxycholic acid (UDCA) in cholestasis. CYP3A is of key importance in human drug metabolism, being involved in presystemic extraction of more than 50% of all drugs currently available and of various endogenous
Inflammation and infection may have the potential to increase the bioavailability of drugs. This effect could be because of a reduced metabolism of xenobiotics in the liver and/or the intestines, or because of alterations in small intestinal permeability, mucosal flow, and expression of drug efflux