CYP1A2*1C, CYP2E1*5B, and GSTM1 polymorphisms are predictors of risk and poor outcome in head and neck squamous cell carcinoma patients
✍ Scribed by Eloisa Helena Ribeiro Olivieri; Sabrina Daniela da Silva; Fernando Fernandes Mendonça; Yuri Nagamine Urata; Daniel Onofre Vidal; Marcilia de Araujo Medrado Faria; Inês Nobuko Nishimoto; Claudia Aparecida Rainho; Luiz Paulo Kowalski; Silvia Regina Rogatto
- Book ID
- 113833185
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 332 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1368-8375
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We investigated the genetic polymorphisms of CYP1A1, CYP2E1 and GSTM1 in Japanese esophageal cancer patients (n = 53) with a histological diagnosis of squamous-cell carcinoma, to determine whether susceptibility to esophageal cancer is associated with these polymorphisms. There were no significant d
## Abstract ## Background. Alcohol intake and tobacco smoke, in addition to other environmental and genetic factors, have been associated with head and neck cancer. We evaluated the role of metabolic enzyme polymorphisms on the risk of head and neck cancer in a hospital‐based case‐control study.