Genetic polymorphisms of CYP1A1, CYP2E1, GSTM1, and GSTT1 associated with head and neck cancer

✍ Scribed by Gilka Jorge Figaro Gattás; Marcos Brasilino de Carvalho; Maria Salete Siraque; Otávio A. Curioni; Priscila Kohler; Jose Eluf-Neto; Victor Wünsch-Filho

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 137 KB
• Volume: 28
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.20410

✦ Synopsis

Abstract

Background.

Alcohol intake and tobacco smoke, in addition to other environmental and genetic factors, have been associated with head and neck cancer. We evaluated the role of metabolic enzyme polymorphisms on the risk of head and neck cancer in a hospital‐based case‐control study.

Methods.

__CYP1A1Msp__I, __CYP2E1Pst__I, GSTM1, and __GSTT1__polymorphisms were evaluated in 103 histologically confirmed head and neck cancer cases and 102 controls by means of polymerase chain reaction–restriction fragment length polymorphism methods.

Results.

__GSTM1__null increased the risk of head and neck cancer (odds ratio [OR], 2.2; 95% confidence interval [95% CI], 1.24–3.79), oral cancer (OR, 2.8; 95% CI, 1.28–5.98), and pharyngeal cancer (OR, 2.2; 95% CI, 1.08–4.63). __CYP2E1Pst__I polymorphism indicated a risk for oral cancer (OR, 3.6; 95% CI, 1.29–11.56). The joint effect of GSTM1 null and CYP1A1 polymorphism increased the risk of head and neck cancer (OR, 2.4; 95% CI, 1.13–5.10).

Conclusions.

GSTM1 null alone or associated with CYP1A1 increased the risk of head and neck cancer; the __CYP2E1Pst__I mutated allele increased the risk for only oral cancer. © 2006 Wiley Periodicals, Inc. Head Neck, 2006.