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CYP1A1 CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus

✍ Scribed by Shunji Morita; Masahiko Yano; Hitoshi Shiozaki; Toshimasa Tsujinaka; Chikara Ebisui; Takashi Morimoto; Masanori Kishibuti; Junya Fujita; Atsuhiro Ogawa; Masaaki Taniguchi; Masatoshi Inoue; Shigeyuki Tamura; Keiji Yamazaki; Nobuteru Kikkawa; Sumio Mizunoya; Morito Monden

Publisher: John Wiley and Sons
Year: 1997
Tongue: French
Weight: 43 KB
Volume: 71
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19970410)71:2<192::aid-ijc11>3.0.co;2-k

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✦ Synopsis

We investigated the genetic polymorphisms of CYP1A1, CYP2E1 and GSTM1 in Japanese esophageal cancer patients (n = 53) with a histological diagnosis of squamous-cell carcinoma, to determine whether susceptibility to esophageal cancer is associated with these polymorphisms. There were no significant differences in the frequency distribution of any one of the 3 polymorphisms between esophageal cancer patients and 132 healthy Japanese controls. The genotype distributions in tobacco smokers or alcohol drinkers were also quite similar for male patients and male controls. The age at onset of esophageal cancer was also similar for patients with any genotype of the 3 polymorphisms. We conclude that the 3 polymorphisms are unlikely to be associated with esophageal cancer susceptibility.

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