We investigated the genetic polymorphisms of CYP1A1, CYP2E1 and GSTM1 in Japanese esophageal cancer patients (n = 53) with a histological diagnosis of squamous-cell carcinoma, to determine whether susceptibility to esophageal cancer is associated with these polymorphisms. There were no significant d
โฆ LIBER โฆ
Genetic polymorphisms of p53 and GSTP1,but not NAT2,are associated with susceptibility to squamous-cell carcinoma of the esophagus
โ Scribed by Jang-Ming Lee; Yung-Chie Lee; Shi-Yi Yang; Wan-Luen Shi; Chun-Jean Lee; Shi-Ping Luh; Chien-Jen Chen; Chang-Yao Hsieh; Ming-Tsang Wu
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 79 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0020-7136
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We examined the effect of genetic polymorphisms of phase-II enzymes, glutathione S-transferase P1 (GSTP1) and N-acetyltrans-ferase2 (NAT2) on susceptibility to esophageal squamous-cell carcinoma. To determine the genotypes of the 2 polymorphisms, PCR-based analysis was performed on samples from 66 J