Association between genetic polymorphisms of glutathione S-transferase P1 and N-acetyltransferase 2 and susceptibility to squamous-cell carcinoma of the esophagus

✍ Scribed by Shunji Morita; Masahiko Yano; Toshimasa Tsujinaka; Atsuhiro Ogawa; Masaaki Taniguchi; Katsuhiko Kaneko; Hitoshi Shiozaki; Yuichiro Doki; Masatoshi Inoue; Morito Monden

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: French
• Weight: 75 KB
• Volume: 79
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/(sici)1097-0215(19981023)79:5<517::aid-ijc12>3.0.co;2-z

✦ Synopsis

We examined the effect of genetic polymorphisms of phase-II enzymes, glutathione S-transferase P1 (GSTP1) and N-acetyltrans-ferase2 (NAT2) on susceptibility to esophageal squamous-cell carcinoma. To determine the genotypes of the 2 polymorphisms, PCR-based analysis was performed on samples from 66 Japanese patients who had been histologically diagnosed as having esophageal squamous-cell carcinoma, and 164 healthy Japanese controls. The frequency of the AA genotype of GSTP1 was significantly higher in esophageal-cancer patients than in the controls according to logistic-regression analysis (92% of the patients and 68% of the controls; odds ratio (OR), 8.0; p ‫؍‬ 0.0013). Also, more patients had the slow and intermediate acetylator genotypes of NAT2 than the controls (15% and 38% vs. 10% and 32% respectively; OR of the slow acetylator genotype, 4.2; p ‫؍‬ 0.032; OR of the slow plus intermediate acetylator genotypes, 2.9; p ‫؍‬ 0.015). Polymorphisms of GSTP1 and NAT2 may serve as genetic biomarkers for predicting susceptibility to esophageal squamous-cell carcinoma.