Cyclophosphamide versus ifosfamide: preliminary report of a randomized phase II trial in adult soft tissue sarcomas
β Scribed by Vivien H. C. Bramwell; H. T. Mouridsen; A. Santoro; G. Blackledge; R. Somers; D. Thomas; R. Sylvester; Allan Van Oosterom
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 442 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
In a phase II study, 16 adult patients with locally advanced or metastatic soft tissue sarcomas were treated with i.v. infusions of ifosfamide/mesna 5 g/m2 plus i.v. doxorubicin 40 mg/m2. Courses were given every 3 weeks up to a maximum of six courses in responding patients. Six patients (37.5%) had
Thirty-four patients with advanced soft tissue sarcomas were entered in a phase II trial of echinomycin. Patients received 1.2 mg/m 2 intravenously (i.v.) weekly times four followed by a two week rest period. There were no objective responses. Dose limiting toxicity was gastrointestinal. Echinomycin
## Abstract ## BACKGROUND The objective of this study was to assess the efficacy and toxicity of the imidazotetrazine derivative temozolomide for patients with unresectable or metastatic soft tissue sarcoma. ## METHODS Twentyβfive of 26 patients were eligible and assessable for toxicity and resp