## Abstract The overexpression of cyclooxygenaseβ2 (COXβ2) and inducible nitric oxide synthase (iNOS) has been previously reported in head and neck squamous cell carcinoma (HNSCC), as well as in many cancers. We hypothesized that endogenous nitric oxide (NO) might increase the expression of COXβ2 i
β¦ LIBER β¦
Cyclooxygenase-2 (COX-2) independent tumor-killing effect of chemical COX-2 inhibitors compared to small interfering RNA of COX-2 in head and neck cancer cell lines
β Scribed by S.W. Park; M.W. Sung
- Book ID
- 118624825
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 239 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1359-6349
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## Abstract ## Background. The protooncogenes Etsβ1 and Etsβ2 are involved in carcinogenesis of different tumors. Nimesulide, a selective cyclooxygenaseβ2 (COXβ2) inhibitor, has antiproliferative effects on tumor cells. The question arises whether nimesulide influences Etsβ1 and Etsβ2 synthesis in