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T1150 Role of Cyclooxygenase-2 in Cancer Stem Cell Biology and Effect of COX-2 Inhibitors in Anti-Cancer Therapy Targeting Cancer Stem Cells

✍ Scribed by Tsujii, Masahiko; Kondo, Jumpei; Akasaka, Tomofumi; Jin, Ying; Hayashi, Yoshito; Inoue, Takahiro; Nakajima, Sachiko; Shinzaki, Shinichiro; Egawa, Satoshi; Nishida, Tsutomu; Watabe, Kenji; Iijima, Hideki; Tsutsui, Shusaku; Hayashi, Norio


Book ID
122065678
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
91 KB
Volume
138
Category
Article
ISSN
0016-5085

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## Abstract The overexpression of cyclooxygenase‐2 (COX‐2) and inducible nitric oxide synthase (iNOS) has been previously reported in head and neck squamous cell carcinoma (HNSCC), as well as in many cancers. We hypothesized that endogenous nitric oxide (NO) might increase the expression of COX‐2 i